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Bromsulphthalein

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 0.14 HEK293-OATP1B1 Cui, 2001
SLCO1B3 OATP1B3, OATP8 3.3 HEK293-OATP1B3 Cui, 2001
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 0.3 OATP1B1-expressing oocytes Kullak-Ublick, 2001
SLCO1B3 OATP1B3, OATP8 0.4 OATP1B3-expressing oocytes Kullak-Ublick, 2001
SLCO2B1 OATP2B1, OATP-B 0.7 OATP2B1-expressing oocytes Kullak-Ublick, 2001
SLCO1A2 OATP1A2, OATP-A ND OATP1A2-expressing oocytes Kullak-Ublick, 2001
SLCO1B3 OATP1B3, OATP8 2.2 MDCKII-ABCC2-OATP1B3 Kopplow, 2005

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B3 OATP1B3, OATP8 Bromsulphthalein 3 Amanitin MDCK II-OATP1B3 Letschert, 2006
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Bromsulphthalein 0.7 0.6 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B1 Annaert, 2010
SLCO1B3 OATP1B3, OATP8 Bromsulphthalein 1.4 1 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B3 Annaert, 2010
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Bromsulphthalein 0.05 Demethylphalloin HEK293 cells Fehrenbach, 2003
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Bromsulphthalein 0.08 Estradiol-17beta-glucuronide HeLa-OATP1B1 Tirona, 2003
SLCO1A2 OATP1A2, OATP-A Bromsulphthalein 3.75 Estrone sulfate COS1-OATP1A2 Lan, 2009
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Bromsulphthalein 1.7 Estrone sulfate COS1-OATP1A2 Lan, 2009
SLCO2B1 OATP2B1, OATP-B Bromsulphthalein 1.7 Estrone sulfate COS1-OATP2B1 Lan, 2009
SLCO2B1 OATP2B1, OATP-B Bromsulphthalein 2 1.5 Estrone sulfate Caco-2 Annaert, 2010
SLCO2B1 OATP2B1, OATP-B Bromsulphthalein 6 Estrone sulfate MDCK II-OATP2B1 Kis, 2010
SLC10A1 NTCP Bromsulphthalein 7.3 Taurocholate HeLa-NTCP Kim, 1999

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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