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Dabrafenib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A6 OAT1 Dabrafenib 6.9 6-CF S2-OAT1 Ellens, 2017
SLC22A8 OAT3 Dabrafenib 3.4 6-CF S2-OAT3 Ellens, 2017
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Dabrafenib 1.4 Estradiol-17beta-glucuronide CHO-OATP1B1 Ellens, 2017
SLCO1B3 OATP1B3, OATP8 Dabrafenib 4.7 Estradiol-17beta-glucuronide HEK-MSRII-OATP1B3 Ellens, 2017

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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