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Everolimus

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Everolimus 11.3 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Everolimus 84 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Everolimus 95 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Everolimus 0.23 Estradiol-17beta-glucuronide HEK-OATP1B1 Farasyn, 2019
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Everolimus 0.16 Estrone sulfate HEK-OATP1B1 Farasyn, 2019
SLCO1B3 OATP1B3, OATP8 Everolimus 3.7 Mycophenolic acid 7-O-glucuronide HEK293-OATP1B3 Farasyn, 2019
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Everolimus 0.19 Rosuvastatin HEK-OATP1B1 Farasyn, 2019
ABCB11 BSEP Everolimus 2 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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