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Ezetimibe

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO2B1 OATP2B1, OATP-B Ezetimibe 1.8 Dibromofluorescein HEK293-OATP2B1 Unger, 2020
ABCC2 MRP2, cMOAT Ezetimibe >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Ezetimibe >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Ezetimibe >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A5 OCTN2 Ezetimibe 29.3 L-carnitine MDCKII-hOCTN2 Diao, 2010
ABCG2 BCRP, MXR Ezetimibe 2.9 Rosuvastatin polarized Caco-2 monolayer Elsby, 2016
ABCB11 BSEP Ezetimibe 56 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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