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Imipramine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A2 OCT2 Imipramine 3.9 1-methyl-4-phenylpyridinium (MPP+) CHO-OCT2 Belzer, 2013
SLC22A2 OCT2 Imipramine 28.9 1-methyl-4-phenylpyridinium (MPP+) CHO-OCT2 Severance, 2017
SLC22A2 OCT2 Imipramine 4.9 1-methyl-4-phenylpyridinium (MPP+) CHO-OCT2 Sandoval, 2018
SLC22A1 OCT1 Imipramine 17.1 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2008
SLC47A1 MATE1 Imipramine 10 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE1 Kido, 2011
SLC47A2 MATE2K Imipramine 100 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Kido, 2011
SLC22A1 OCT1 Imipramine 7.95 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Chen, 2017
SLC22A2 OCT2 Imipramine 0.5 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) CHO-OCT2 Sandoval, 2018
ABCC2 MRP2, cMOAT Imipramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Imipramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Imipramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A2 OCT2 Imipramine 0.77 Metformin CHO-OCT2 Belzer, 2013
SLC22A2 OCT2 Imipramine 0.4 Metformin CHO-OCT2 Sandoval, 2018
SLC22A1 OCT1 Imipramine 6.2 Morphine HEK293-OCT1 Tzvetkov, 2013
SLC22A1 OCT1 Imipramine 4.03 Morphine HEK293-OCT1 Zhu, 2018
SLC22A3 OCT3 Imipramine 42 N-methylpyridinium HRPE-OCT3 Wu, 2000
SLC22A2 OCT2 Imipramine 6 N-methylpyridinium HEK293-OCT2 Zolk, 2009
SLC22A2 OCT2 Imipramine 1.4 NBD-MTMA CHO-OCT2 Belzer, 2013
SLC22A2 OCT2 Imipramine 1.4 NBD-MTMA CHO-OCT2 Sandoval, 2018
ABCB11 BSEP Imipramine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC47A1 MATE1 Imipramine 42 Tetraethylammonium HEK293-MATE1 Tsuda, 2009
SLC47A2 MATE2K Imipramine 182.9 Tetraethylammonium HEK293-MATE2 Tsuda, 2009
SLC22A2 OCT2 Imipramine 1.3 Tetraethylammonium CHO-OCT2 Sandoval, 2018

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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