| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| ABCB1 |
MDR1, P-gp |
Lansoprazole |
62.8 |
| Digoxin |
Caco-2 cells |
Pauli-Magnus, 2001 |
| ABCC2 |
MRP2, cMOAT |
Lansoprazole |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| ABCC3 |
MRP3 |
Lansoprazole |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| ABCC4 |
MRP4 |
Lansoprazole |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| SLC22A1 |
OCT1 |
Lansoprazole |
35.8 |
| Metformin |
HEK293-OCT1 |
Nies, 2011 |
| SLC22A2 |
OCT2 |
Lansoprazole |
9.5 |
| Metformin |
HEK293-OCT2 |
Nies, 2011 |
| SLC22A2 |
OCT2 |
Lansoprazole |
3.28 |
| Metformin |
HEK293-OCT2 |
Hacker, 2015 |
| ABCG2 |
BCRP, MXR |
Lansoprazole |
14.4 |
| Methotrexate |
BCRP membrane vesicles |
Suzuki, 2009 |
| SLC22A8 |
OAT3 |
Lansoprazole |
0.4 |
| Methotrexate |
HEK293-OAT3 |
Narumi, 2017 |
| SLC22A2 |
OCT2 |
Lansoprazole |
13 |
| Para-Aminosalicylic acid (PAS) |
HEK293-OCT2 |
Parvez, 2017 |
| SLC22A6 |
OAT1 |
Lansoprazole |
4.13 |
| Para-Aminosalicylic acid (PAS) |
HEK293-OAT1 |
Parvez, 2017 |
| SLC22A8 |
OAT3 |
Lansoprazole |
2.18 |
| Para-Aminosalicylic acid (PAS) |
HEK293-OAT3 |
Parvez, 2017 |
| ABCB11 |
BSEP |
Lansoprazole |
>133 |
| Taurocholate |
Sf9 cell membrane vesicles |
Morgan, 2013 |
