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Lidocaine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Lidocaine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Lidocaine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Lidocaine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Lidocaine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A4 OCTN1 Lidocaine 0.83 Tetraethylammonium HEK293-hOCTN1 Peltekova, 2004
SLC22A2 OCT2 Lidocaine 104.6 86.8 Tetraethylammonium S2-OCT2 Chiba, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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