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Nifekalant

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Nifekalant >300 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Wittwer, 2013
SLC22A3 OCT3 Nifekalant 146 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT3 Wittwer, 2013
SLC22A2 OCT2 Nifekalant 10.3 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT2 Wittwer, 2013
SLC47A1 MATE1 Nifekalant 6.5 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE1 Wittwer, 2013
SLC47A2 MATE2K Nifekalant 2.7 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Wittwer, 2013
SLC47A2 MATE2K Nifekalant 6.5 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Wittwer, 2013
SLC47A1 MATE1 Nifekalant 0.65 Metformin MDCK2- MATE1 Wittwer, 2013
SLC47A1 MATE1 Nifekalant 1.1 Metformin HEK293-MATE1 Wittwer, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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