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Rifabutin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Rifabutin 42.7 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Parvez, 2016
ABCC2 MRP2, cMOAT Rifabutin 49.8 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Rifabutin 15.9 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Rifabutin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Rifabutin 35.4 Estrone sulfate HEK-OATP1B1 Parvez, 2016
SLC22A8 OAT3 Rifabutin 54 Estrone sulfate HEK293-OAT3 Parvez, 2016
SLC22A1 OCT1 Rifabutin 38.7 Metformin HEK293-OCT1 Parvez, 2016
SLC22A6 OAT1 Rifabutin 55.1 PAH HEK293-OAT1 Parvez, 2016
ABCB11 BSEP Rifabutin 26.7 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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