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Sunitinib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Sunitinib 67 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Johnston, 2014
SLC22A1 OCT1 Sunitinib 6.1 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Chen, 2017
ABCG2 BCRP, MXR Sunitinib 0.64 0.32 Estrone sulfate BCRP membrane vesicles Kawahara, 2010
SLC22A1 OCT1 Sunitinib 0.33 Metformin HEK293-OCT1 Minematsu, 2011
SLC47A1 MATE1 Sunitinib 0.275 Metformin HEK293-MATE1 Minematsu, 2011
SLC47A2 MATE2K Sunitinib 0.86 Metformin HEK293-MATE2K Minematsu, 2011

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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