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Tacrine

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC47A1	MATE1	Tacrine	0.51	1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE1	Astorga, 2012
SLC47A2	MATE2K	Tacrine	1.1	1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE2K	Astorga, 2012
SLC22A2	OCT2	Tacrine	2.3	1-methyl-4-phenylpyridinium (MPP+)	CHO-OCT2	Sandoval, 2018
SLC22A1	OCT1	Tacrine	83	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Kido, 2011
SLC47A1	MATE1	Tacrine	1.1	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE1	Kido, 2011
SLC47A2	MATE2K	Tacrine	100	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE2K	Kido, 2011
SLC22A1	OCT1	Tacrine	21.72	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Chen, 2017
SLC22A2	OCT2	Tacrine	0.4	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	CHO-OCT2	Sandoval, 2018
ABCC4	MRP4	Tacrine	23.7	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC2	MRP2, cMOAT	Tacrine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Tacrine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Tacrine	0.6	Metformin	CHO-OCT2	Sandoval, 2018
SLC22A2	OCT2	Tacrine	1	NBD-MTMA	CHO-OCT2	Sandoval, 2018
ABCB11	BSEP	Tacrine	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Tacrine	0.9	Tetraethylammonium	CHO-OCT2	Sandoval, 2018

No drug-drug interaction information.