UCSF home page | About UCSF | UCSF Medical Center

Skip to TransPortal content

Enlarge Text
Click to increase the text size. Restore Text
Click to restore original text size. Reduce Text
Click to decrease the text size.


Decrease the text size \| Restore text size \| Increase the text size

Trospium

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A1	OCT1	17	HEK293-OCT1	Wenge, 2011
SLC22A1	OCT1	106	HEK293-OCT1	Bexten, 2015
SLC47A2	MATE2K	8.2	HEK293-MATE2K	Chen, 2017
SLC22A1	OCT1	15	HEK293-OCT1	Chen, 2017
SLC47A1	MATE1	15.4	HEK293-MATE1	Chen, 2017
SLC22A2	OCT2	2.1	MDCK-OCT2	Deutsch, 2019

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Trospium	18.1	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Wenge, 2011
SLC22A1	OCT1	Trospium	15	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Chen, 2017
SLC47A1	MATE1	Trospium	11.6	1-methyl-4-phenylpyridinium (MPP+)	HEK293-MATE1	Chen, 2017
SLC47A2	MATE2K	Trospium	5.1	1-methyl-4-phenylpyridinium (MPP+)	HEK293-MATE2K	Chen, 2017

No drug-drug interaction information.