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Valinomycin

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	1	MDR1-containing proteoliposomes	Borgnia, 1996
ABCB1	MDR1, P-gp	2.5	ATPase assay of Sf9-MDR1 liposomes	Kimura, 2007

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Valinomycin	3.2	Daunorubicin	NIH-G185 cells	Wang, 2001
ABCC2	MRP2, cMOAT	Valinomycin	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Valinomycin	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Valinomycin	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCB11	BSEP	Valinomycin	0.7	Taurocholate	BSEP-expressing Sf9 vesicles	Kis, 2009
ABCB11	BSEP	Valinomycin	1.56	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.