Transporter Localization in the Blood-Brain Barrier
Brain Interstitial Space Basolateral
--------------------- OCTN1 ----- OCTN2 ----- OAT3 -----------------------
| | | | |
| \_/ \_/ \_/ |
| |
| Brain capillary endothelial cells |
| |
| _ _ |
| / \ / \ |
| | | |
--- OATP1A2 -- OATP2B1 -- MDR1 -- BCRP -- MRP1 -- MRP2 -- MRP4 -- MRP5 ---
Blood | | | | | | Apical/luminal
\_/ \_/ \_/ \_/ \_/ \_/
arrows denote primary direction of transport
The image shows a simplified cell outline with marked basolateral side facing the brain interstitial space and apical/luminal side facing the blood. OCTN1, OCTN2, and OAT3 are placed as influx transporters on the basolateral side. OATP1A2 and OATP2B1 are apical influx transporters; while MDR1, BCRP, MRP1, MRP2, MRP4, and MRP5 are apical efflux transporters.