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Intestinal Epithelia

Localization Information

text version of image
image associated links:
basolateral genes: OCT1, MRP1, MRP3, OSTalpha, OSTbeta
apical genes: OCT3, OCTN1, OCTN2, OATP1A2, OATP2B1, MRP2, MDR1, BCRP, PEPT1, ASBT

Notes:

The arrows indicate the transporter's primary direction of transport. However, for some SLC transporters, transport in the opposite direction is also possible. For example, efflux of preloaded acetylcholine has been observed from both OCT1 and OCT2-expressing oocytes (Lips et al., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88).
The orange transporter MCT1 is shown, but not currently contained in our database.

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Relative Expression (Transporter mRNA/PPIA mRNA)
ABCB1*	MDR1, P-gp	`0.0337`
ABCB4	MDR3	`0.000614`
ABCB11	BSEP	BLQ
ABCC1*	MRP1	`0.0184`
ABCC2*	MRP2, cMOAT	`0.0273`
ABCC3*	MRP3	`0.0513`
ABCC4	MRP4	`0.0396`
ABCC5	MRP5	`0.00820`
ABCC6	MRP6	`0.000960`
ABCG2*	BCRP, MXR	`0.0492`
SLC10A1	NTCP	`0.00138`
SLC10A2*	ASBT, SBAT2	`0.0902`
SLC15A1*	PEPT1	`0.148`
SLC15A2	PEPT2	`0.000804`
SLC22A1*	OCT1	`0.0000241`
SLC22A2	OCT2	BLQ
SLC22A3*	OCT3	`0.0256`
SLC22A4*	OCTN1	`0.00694`
SLC22A5*	OCTN2	`0.0136`
SLC22A6	OAT1	BLQ
SLC22A7	OAT2	`0.000686`
SLC22A8	OAT3	BLQ
SLC22A11	OAT4	BLQ
SLC22A12	URAT1	BLQ
SLCO1A2*	OATP1A2, OATP-A	`0.0000198`
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	BLQ
SLCO2B1*	OATP2B1, OATP-B	`0.0277`

(n=5): male & female, 20 to 61-yr, Caucasian
BLQ = below limit of quantitation